Best way to travel between Cuzco, Peru and Santiago

A: Cuzco, Peru

B: Santiago

Travel Modes: Price; Distance; Duration; CO2

bus: $132.74; 2968.39 km; 38h 53mins; 89.05 kgs

bus: $207.0; 3023.94 km; 40h 28mins; 90.72 kgs

flight: $334.0; 2344.65 km; 4h 23mins; 253.22 kgs

drive: $370.0; 2951.88 km; 37h 13mins; 377.84 kgs

train: $736.74; 2990.64 km; 41h 38mins; 158.5 kgs

Tranport	Distance	Time(hrs)	Cost(local)	Cost(usd)
Bus	2968.39 km	38h 53mins	69,302 CLP	132.74
Bus	3023.94 km	40h 28mins	108,072 CLP	207.0
Flight	2344.65 km	4h 23mins	174,377 CLP	334.0
Drive	2951.88 km	37h 13mins	193,172 CLP	370.0
Train	2990.64 km	41h 38mins	384,642 CLP	736.74

Take Bus from Cusco to Puno: Time: 6h 34mins Cost: 10,964 CLP; $ 18.9 - 23.1 USD CO2 Emission: 11.89 kgs
Take Bus from Puno to Tacna: Time: 8h 5mins Cost: 8,740 CLP; $ 15.1 - 18.4 USD CO2 Emission: 12.68 kgs
Take Bus from Tacna to Santiago: Time: 22h 13mins Cost: 49,598 CLP; $ 85.5 - 104.5 USD CO2 Emission: 64.51 kgs

Source: Rome2rio

Mode of travel comparision chart

The best and cheapest way to get from Cuzco, Peru and Santiago is to travel by bus, which will cost about 69,437 CLP or 119.70 USD.