Best way to travel between Istanbul, Turkey and Italy

A: Istanbul, Turkey

B: Italy

Travel Modes: Price; Distance; Duration; CO2

bus: $36.26; 1816.67 km; 30h 16mins; 54.5 kgs

train: $53.04; 2893.98 km; 52h 27mins; 153.38 kgs

flight: $172.48; 1056.45 km; 3h 17mins; 114.1 kgs

drive: $351.75; 2224.81 km; 20h 58mins; 284.78 kgs

Tranport	Distance	Time(hrs)	Cost(local)	Cost(usd)
Bus	1816.67 km	30h 16mins	27 EUR	36.26
Train	2893.98 km	52h 27mins	39 EUR	53.04
Flight	1056.45 km	3h 17mins	127 EUR	172.48
Drive	2224.81 km	20h 58mins	259 EUR	351.75

Take Train from Aksaray to Otogar: Time: 12mins Cost: 1 EUR; $ 0.9 - 1.1 USD CO2 Emission: 0.37 kgs
Take Bus from Istanbul to Struga: Time: 16h 30mins Cost: 27 EUR; $ 32.4 - 39.6 USD CO2 Emission: 28.51 kgs
Take Bus from Struga to Bari: Time: 6h 30mins Cost: 18 EUR; $ 21.6 - 26.4 USD CO2 Emission: 11.45 kgs
Take Train from Bari Centrale to Roma Termini: Time: 4h 4mins Cost: 37 EUR; $ 45.0 - 55.0 USD CO2 Emission: 25.32 kgs

Source: Rome2rio

Mode of travel comparision chart

The best and cheapest way to get from Istanbul, Turkey and Italy is to travel by bus, which will cost about 27 EUR or 32.40 USD.