Best way to travel between Istanbul, Turkey and Niš

A: Istanbul, Turkey

B: Niš

Travel Modes: Price; Distance; Duration; CO2

train: $15.84; 750.75 km; 17h 40mins; 39.79 kgs

bus: $30.87084; 716.91 km; 13h 29mins; 21.51 kgs

flight: $74.1; 660.82 km; 2h 25mins; 71.37 kgs

drive: $82.62; 714.07 km; 7h 5mins; 91.4 kgs

Tranport	Distance	Time(hrs)	Cost(local)	Cost(usd)
Train	750.75 km	17h 40mins	58 AED	15.84
Bus	716.91 km	13h 29mins	113 AED	30.87084
Flight	660.82 km	2h 25mins	272 AED	74.1
Drive	714.07 km	7h 5mins	303 AED	82.62

Take Train from Yenikapi to Halkali: Time: 32mins Cost: 4 AED; $ 0.9 - 1.1 USD CO2 Emission: 1.15 kgs
Take Train from Halkali to Sofia: Time: 11h 2mins Cost: 55 AED; $ 13.5 - 16.5 USD CO2 Emission: 29.86 kgs
Take Walk from Sofia to Sofia: Time: 6mins Cost: 0 AED; $ 0.0 - 0.0 USD CO2 Emission: 0.07 kgs
Take Bus from Sofia to Niš: Time: 4h 0mins Cost: 40 AED; $ 9.9 - 12.1 USD CO2 Emission: 4.95 kgs

Source: Rome2rio

Mode of travel comparision chart

The best and cheapest way to get from Istanbul, Turkey and Niš is to travel by train, which will cost about 59 AED or 14.40 USD.