Best way to travel between Istanbul, Turkey and Rome

A: Istanbul, Turkey

B: Rome

Travel Modes: Price; Distance; Duration; CO2

bus: $161.0; 3151.05 km; 56h 5mins; 94.53 kgs

train: $231.0; 1838.55 km; 39h 35mins; 97.44 kgs

flight: $240.0; 1467.53 km; 6h 45mins; 158.49 kgs

drive: $480.0; 2247.25 km; 24h 40mins; 287.65 kgs

Tranport	Distance	Time(hrs)	Cost(local)	Cost(usd)
Bus	3151.05 km	56h 5mins	119 EUR	161.0
Train	1838.55 km	39h 35mins	170 EUR	231.0
Flight	1467.53 km	6h 45mins	177 EUR	240.0
Drive	2247.25 km	24h 40mins	353 EUR	480.0

Take Bus from Istanbul to Razgrad: Time: 11h 2mins Cost: 37 EUR; $ 45.0 - 55.0 USD CO2 Emission: 17.52 kgs
Take Bus from Razgrad to Bucuresti: Time: 2h 20mins Cost: 20 EUR; $ 24.3 - 29.7 USD CO2 Emission: 4.68 kgs
Take Bus from Bucureşti to Termini: Time: 40h 38mins Cost: 63 EUR; $ 76.5 - 93.5 USD CO2 Emission: 72.34 kgs

Source: Rome2rio

Mode of travel comparision chart

The best and cheapest way to get from Istanbul, Turkey and Rome is to travel by bus, which will cost about 119 EUR or 144.90 USD.