Best way to travel between Madrid and Istanbul, Turkey

A: Madrid

B: Istanbul, Turkey

Travel Modes: Price; Distance; Duration; CO2

bus: $172.95; 3899.7 km; 60h 10mins; 116.99 kgs

flight: $308.0; 2898.42 km; 8h 17mins; 313.03 kgs

train: $520.0; 4032.08 km; 51h 49mins; 213.7 kgs

drive: $700.0; 3588.36 km; 37h 51mins; 459.31 kgs

Tranport	Distance	Time(hrs)	Cost(local)	Cost(usd)
Bus	3899.7 km	60h 10mins	348 TRY	172.95
Flight	2898.42 km	8h 17mins	620 TRY	308.0
Train	4032.08 km	51h 49mins	1,047 TRY	520.0
Drive	3588.36 km	37h 51mins	1,409 TRY	700.0

Take Train from Alonso Martínez to Avenida de América: Time: 14mins Cost: 4 TRY; $ 1.8 - 2.2 USD CO2 Emission: 0.18 kgs
Take Bus from Madrid to Sofia: Time: 48h 39mins Cost: 254 TRY; $ 113.4 - 138.6 USD CO2 Emission: 99.19 kgs
Take Bus from Sofia to Istanbul: Time: 9h 11mins Cost: 91 TRY; $ 40.5 - 49.5 USD CO2 Emission: 17.7 kgs

Source: Rome2rio

Mode of travel comparision chart

The best and cheapest way to get from Madrid and Istanbul, Turkey is to travel by bus, which will cost about 348 TRY or 155.70 USD.