Best way to travel between Prague and Italy

A: Prague

B: Italy

Travel Modes: Price; Distance; Duration; CO2

flight: $98.0; 980.22 km; 4h 25mins; 105.86 kgs

bus: $110.0; 1512.98 km; 25h 3mins; 45.39 kgs

train: $190.0; 1551.18 km; 20h 8mins; 82.21 kgs

drive: $280.0; 1316.03 km; 12h 22mins; 168.45 kgs

Tranport	Distance	Time(hrs)	Cost(local)	Cost(usd)
Flight	980.22 km	4h 25mins	72 EUR	98.0
Bus	1512.98 km	25h 3mins	81 EUR	110.0
Train	1551.18 km	20h 8mins	140 EUR	190.0
Drive	1316.03 km	12h 22mins	206 EUR	280.0

Take Bus from Praha, Hradčanská to Praha, Letiště Václava Havla: Time: 15mins Cost: 0 EUR; $ 0.6 - 0.7 USD CO2 Emission: 0.46 kgs
Take Flight from PRG to CIA: Time: 1h 47mins Cost: 70 EUR; $ 85.5 - 104.5 USD CO2 Emission: 102.76 kgs
Take Train from Ciampino to Roma Termini: Time: 15mins Cost: 1 EUR; $ 0.9 - 1.1 USD CO2 Emission: 0.74 kgs

Source: Rome2rio

Mode of travel comparision chart

The best and cheapest way to get from Prague and Italy is to travel by air, which will cost about 72 EUR or 88.20 USD.