Best way to travel between Rome and Istanbul, Turkey

A: Rome

B: Istanbul, Turkey

Travel Modes: Price; Distance; Duration; CO2

train: $197.0; 1839.6 km; 39h 34mins; 97.5 kgs

bus: $213.0; 2949.2 km; 53h 50mins; 88.48 kgs

flight: $238.0; 1484.1 km; 6h 28mins; 160.28 kgs

drive: $480.0; 2323.36 km; 25h 17mins; 297.39 kgs

Tranport	Distance	Time(hrs)	Cost(local)	Cost(usd)
Train	1839.6 km	39h 34mins	397 TRY	197.0
Bus	2949.2 km	53h 50mins	429 TRY	213.0
Flight	1484.1 km	6h 28mins	479 TRY	238.0
Drive	2323.36 km	25h 17mins	966 TRY	480.0

Take Train from Roma Termini to Bari Centrale: Time: 4h 15mins Cost: 131 TRY; $ 58.5 - 71.5 USD CO2 Emission: 26.33 kgs
Take Ferry from Bari to Durrës: Time: 9h 27mins Cost: 101 TRY; $ 45.0 - 55.0 USD CO2 Emission: 30.05 kgs
Take Bus from Durrës to Istanbul: Time: 23h 46mins Cost: 161 TRY; $ 72.0 - 88.0 USD CO2 Emission: 33.25 kgs

Source: Rome2rio

Mode of travel comparision chart

The best and cheapest way to get from Rome and Istanbul, Turkey is to travel by train, which will cost about 397 TRY or 177.30 USD.