Best way to travel between Santander and Madrid

A: Santander

B: Madrid

Travel Modes: Price; Distance; Duration; CO2

flight: $43.0; 471.45 km; 6h 53mins; 50.92 kgs

bus: $45.0; 473.55 km; 5h 57mins; 14.21 kgs

train: $50.0; 439.81 km; 4h 54mins; 23.31 kgs

drive: $85.0; 472.16 km; 4h 50mins; 60.44 kgs

Tranport	Distance	Time(hrs)	Cost(local)	Cost(usd)
Flight	471.45 km	6h 53mins	32 EUR	43.0
Bus	473.55 km	5h 57mins	33 EUR	45.0
Train	439.81 km	4h 54mins	37 EUR	50.0
Drive	472.16 km	4h 50mins	63 EUR	85.0

Take Bus from Santander to Aeropuerto: Time: 2h 32mins Cost: 8 EUR; $ 9.9 - 12.1 USD CO2 Emission: 3.67 kgs
Take Flight from BIO to MAD: Time: 1h 8mins Cost: 22 EUR; $ 27.0 - 33.0 USD CO2 Emission: 36.07 kgs
Take Train from Aeropuerto T4 to Recoletos: Time: 24mins Cost: 1 EUR; $ 1.8 - 2.2 USD CO2 Emission: 0.81 kgs

Source: Rome2rio

Mode of travel comparision chart

The best and cheapest way to get from Santander and Madrid is to travel by air, which will cost about 32 EUR or 38.70 USD.