Best way to travel between Santiago and Cuzco, Peru

A: Santiago

B: Cuzco, Peru

Travel Modes: Price; Distance; Duration; CO2

bus: $137.0; 3142.11 km; 40h 28mins; 94.26 kgs

bus: $267.38; 4113.9 km; 75h 48mins; 123.42 kgs

flight: $354.0; 2344.65 km; 6h 19mins; 253.22 kgs

drive: $370.0; 2919.91 km; 36h 55mins; 373.75 kgs

train: $1815.0; 3296.64 km; 73h 59mins; 174.72 kgs

Tranport	Distance	Time(hrs)	Cost(local)	Cost(usd)
Bus	3142.11 km	40h 28mins	384 PEN	137.0
Bus	4113.9 km	75h 48mins	750 PEN	267.38
Flight	2344.65 km	6h 19mins	993 PEN	354.0
Drive	2919.91 km	36h 55mins	1,038 PEN	370.0
Train	3296.64 km	73h 59mins	5,090 PEN	1815.0

Take Bus from Santiago to Tacna: Time: 24h 14mins Cost: 266 PEN; $ 85.5 - 104.5 USD CO2 Emission: 64.44 kgs
Take Bus from Tacna to Arequipa: Time: 6h 4mins Cost: 50 PEN; $ 16.2 - 19.8 USD CO2 Emission: 11.16 kgs
Take Bus from Arequipa to Cusco: Time: 8h 35mins Cost: 62 PEN; $ 19.8 - 24.2 USD CO2 Emission: 18.67 kgs

Source: Rome2rio

Mode of travel comparision chart

The best and cheapest way to get from Santiago and Cuzco, Peru is to travel by bus, which will cost about 384 PEN or 123.30 USD.