Best way to travel between Thessaloniki and Rome

A: Thessaloniki

B: Rome

Travel Modes: Price; Distance; Duration; CO2

bus: $142.0; 2400.32 km; 41h 16mins; 72.01 kgs

flight: $175.0; 993.3 km; 4h 17mins; 107.28 kgs

train: $177.0; 1170.59 km; 23h 1mins; 62.04 kgs

drive: $226.0; 1433.12 km; 22h 17mins; 183.44 kgs

Tranport	Distance	Time(hrs)	Cost(local)	Cost(usd)
Bus	2400.32 km	41h 16mins	105 EUR	142.0
Flight	993.3 km	4h 17mins	129 EUR	175.0
Train	1170.59 km	23h 1mins	130 EUR	177.0
Drive	1433.12 km	22h 17mins	166 EUR	226.0

Take Bus from Thessaloniki to Skopje: Time: 4h 41mins Cost: 11 EUR; $ 13.5 - 16.5 USD CO2 Emission: 7.1 kgs
Take Bus from Skopje to Ancona: Time: 28h 5mins Cost: 66 EUR; $ 81.0 - 99.0 USD CO2 Emission: 53.22 kgs
Take Bus from Ancona to Rome: Time: 5h 43mins Cost: 26 EUR; $ 31.5 - 38.5 USD CO2 Emission: 11.36 kgs
Take Bus from Lorenzo Il Magnifico- Pulci to Plebiscito: Time: 33mins Cost: 1 EUR; $ 1.8 - 2.2 USD CO2 Emission: 0.34 kgs

Source: Rome2rio

Mode of travel comparision chart

The best and cheapest way to get from Thessaloniki and Rome is to travel by bus, which will cost about 105 EUR or 127.80 USD.